The Beckmann rearrangement enables the conversion of oximes into amides or lactams via acid-promoted rearrangement with substituent migration. Developed by Ernst Otto Beckmann in the late 19th century, the reaction proceeds through activation of the oxime, rearrangement to a nitrilium intermediate, and subsequent attack of water to yield the amide. Learn. Review. Repeat.

Beckmann Rearrangement | Reaction | Mechanism | Applications