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mTOR
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slideserve.com
The Ras – MAP kinase pathway - SlideServe
The Ras – MAP kinase pathway. I. The big family of Receptor Tyrosine Kinases. Receptor domain architecture and receptor activation by EGF (TGF a ). unusual mode of allosteric activation, formation of an asymmetric dimer, followed by trans-phosphorylation of the C-tails. II. II.
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One good thing in heme/onc: January 20, 2026. Langerhans Cell Histiocytosis (LCH): 5 Clinical Pearls • LCH is a rare clonal myeloid neoplasm driven by MAPK pathway activation (most commonly BRAF V600E). • Adult LCH often presents as single-system disease (bone, lung, or skin) & many patients can be managed with observation alone. • Risk-organ involvement (liver, spleen, bone marrow) predicts prognosis and guides treatment intensity. • Treatment decisions are based on disease behavior and organ i
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