Take a closer look at neurons in the brain. Here, you can see a mouse brain, cleared using CLARITY protocol with final imaging done in EasyIndex. PV-tdtomato was expressed in interneurons throughout the brain and in Purkinje cells in the cerebellum. Image data volume: 11 x 20 x 8.9 mm. Acquired with ZEISS Lightsheet 7: https://zeiss.ly/f-lightsheet7 Sample: courtesy of E. Diel and D. Richardson, Harvard University, Cambridge, USA. #zeiss #lightsheet #microscopy #brain #neurons | ZEISS Microscopy

Imaging entire cells in the human brain is a task close to impossible, due to the tremendously sophisticated morphology of neurons and their spread throughout the entire organ. Organoids (as below) allow the recapitulation of the human brain to a certain extent, including the production of neurons from neuronal stem cell cultures. With ECi clearing, neuronal morphology can be studied from the local to global level, which opens up fascinating possibilities for the study of neuronal morphology in