The impact of neflamapimod on neurofilament light levels will be examined in a study of approximately 35 patients with ALS, facilitated by the EXPERTS-ALS platform, according to a press release from ...

Many cancers involve upregulation of Aurora kinase B, which helps deregulate normal cell cycling to drive tumor proliferation. The kinase should therefore be a good therapeutic target, yet no ...

Structurally, they look similar: MNK1 and MNK2 belong to the same enzyme family and are best known for regulating how cells ...

An international team of scientists has shed light on the development of the malaria parasite and has identified a unique protein essential for its survival and transmission, which offers a promising ...

A new study reveals that the twin enzymes MNK1 and MNK2 play distinct roles in the brain, with one governing memory and the other social behavior.

An illustration shows the structure of an inhibitor bound to the active site of membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase. An inhibitor bound to the active site of ...

Researchers at The Wistar Institute have engineered a small-molecule drug conjugate that has directed an Aurora kinase A inhibitor into tumours via heat shock protein 90 targeting, increased ...

Comparative efficacy of cabozantinib or lenvatinib following atezolizumab plus bevacizumzb in patients with advanced hepatocellular cancer. Development and validation of a prognostic risk score for ...