For many years, researchers believed that the DNA inside a newly fertilized egg began as a structural ‘blank slate’ – a loose, unorganized mass that would only take shape once the embryo started using ...

Scientists discover hidden DNA scaffolding that forms before genes activate, revealing life’s blueprint is built before it begins.

Left: staining for H3K27me3, which marks inactive DNA, on a nucleus of a wildtype embryo consisting of two cells Right: staining for H3K27me3, which marks inactive DNA, on a nucleus of an embryo ...

Researchers from the Kind Group have gained new insights into the mechanism behind the spatial organization of DNA within the cells of early embryos. When an embryo is first formed after fertilization ...

Human DNA constantly refolds in 3D space, and these looping dynamics regulate gene expression and cell identity.

DNA has to be carefully packaged and organized in cells so it will both physically fit into the nucleus, and also remain accessible to the cellular machinery that transcribes active genes. Together, ...

A pioneering study has unveiled that the 3D organization of DNA can influence the progression of the aggressive brain tumor known as glioblastoma. Having identified the factors that glioblastoma uses ...

In a discovery that could redefine how we understand cellular resilience and adaptability, scientists have unlocked the secret interactions between a primordial inorganic polymer of phosphate known as ...

An article by UAB professor Joan-Ramon Daban analyzes in depth the physical problems associated with DNA packaging that have often been neglected in structural models of chromosomes. The study ...

National Eye Institute (NEI) researchers have mapped the organization of human retinal cell chromatin, the fibers that package three billion nucleotide-long DNA molecules into compact structures that ...