I regret to say there is no simple or easy answer to this question. Many people use the word ‘depression’ to refer to normal disappointment or sadness, and there can be little doubt that the concept ...

Several psychiatrists are considering changing guidelines that define depression, due to findings from a new study. Michele Norris talks with Dr. Michael First of Columbia University about expanding ...

Dr. Harold Koenig answers the question: 'What Is Depression?' — -- Question: What is the difference between depression and manic depression (bipolar disorder)? Answer: Depression and manic ...

“Unspecified depressive disorder” is used when someone displays depressive symptoms, but there isn’t enough information for a specific diagnosis. Depressive symptoms can be complex and may not clearly ...

A new study led by Shan Siddiqi, MD, from Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, suggests that depression after traumatic brain injury (TBI) ...

Depression is characterized by a persistent low mood that can affect quality of life. If symptoms usually only occur in the winter months, it may be seasonal affective disorder (SAD), or major ...

The approval of medicines called second-generation antipsychotics has allowed major depressive disorder (MDD) and other conditions linked to it to be treated. A person with MDD is usually prescribed ...

According to the World Health Organization (WHO), about 332 million people around the world live with depression. Milaneschi is the co-lead author of a new study recently presented at the 2025 ECNP ...