Alpha-substituted fatty amines and nitrogen-containing heterocycles are widely found in numerous bioactive natural products, pharmaceutical molecules, and agrochemicals. A recent analysis of small ...

Medicines come from chemical reactions, and better chemical reactions lead to better medicines. Yet, the most popular reaction used in drug discovery, called the amide coupling, makes an inherently ...

Even though amide bonds are everywhere—they hold proteins together and are essential components in many drugs—forging this molecular motif in a reaction flask can be challenging. For example, making ...

Linking molecular components through amide bonds is one of the most important reactions in research and the chemical industry. Scientists have now introduced a new type of reaction for making amide ...

It’s hard to improve on a classic. But Richard Y. Liu was eager to take on that challenge. Cross-coupling reactions, including Suzuki-Miyaura coupling and Buchwald-Hartwig amination, are some of the ...

A single type of chemical structure that shows up again and again in modern medicine is the amide bond that links a carbonyl group (C=O) to a nitrogen atom. They're so ubiquitous that 117 of the top ...

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